Studies on Peptides and Stem Cells

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Stem cells are considered to be an organism’s primary source material, the cells from which all other specialized cells are derived. When placed in the proper environment, stem cells may divide into daughter cells.

These daughter cells may either continue to divide and form more stem cells or differentiate into specialized cells (e.g., blood cells, brain cells, heart muscle cells, and bone cells) with a more defined role in the organism’s physiological functioning. The capacity to naturally create new cell types is unique to stem cells.

Thymosin Beta-4 Peptide

Thymosin beta 4, a protein believed to sequester actin monomers, belongs to a highly conserved family of proteins. All cells contain thymosin -4, a sequence of 43 amino acids encoded by the gene TMSBX4. It has been widely utilized in research studies for years due to its potential to shorten recovery periods from injuries and lessen the severity of delayed onset muscle soreness. Tendon, ligament, muscle damage, pressure or venous stasis ulcers, injuries, immune response regulation, autoimmune disorders in the brain, and spinal cord injuries have all been hypothesized to be aided by TB-4. Studies suggest that Thymosin beta 4 may be involved in tissue healing and its activity may be a key actin-sequestering molecule. Protection, regeneration, and remodeling of damaged or wounded tissues have all been speculated to be linked with T4. It has also been suggested that the T4 gene is among the first to be activated in response to wounds. Together with platelet-rich plasma (PRP), it has been suggested to stimulate stem cells in various ways, though research is ongoing.

Thymosin Beta-4 and Stem Cells

Research suggests that the proliferation of mesenchymal stem cells may be stimulated by Thymosin beta-4 in an IL-8-dependent manner:

This research suggested that T4 may stimulate the growth of ASCs by activating the ERK and NF-B pathways in a manner reliant on IL-8. As a result, T4 has been speculated as a potential research candidate in the context of enlarging MSCs

PEG-MGF Peptide

The sequence of MGF is different from that of the liver-produced systemic IGF-1. Studies suggest that local muscle injury may be aided, and MGF may trigger hypertrophy. Fatigued muscles express muscle growth factor (MGF) and play a tissue repair and adaptation role. It has been purported that PEG-MGF may activate muscle satellite (stem) cells and is expressed in a pulse after muscle injury. These provide the nuclei for muscle fibers throughout the repairing and growing phases, a process called hypertrophy. Research suggests that like IGF-1, MGF may promote cell division and aid healing.

PEG MGF Peptide and Stem Cells

Findings imply that the E peptide may control MGF or Mechano growth factor migration and differentiation of mesenchymal stem cells from bone marrow. Transwell and wound-healing experiments suggested that the MGF E peptide may have improved rBMSCs’ migratory potential.

GHK-Cu Peptide

GHK-Cu was found first in plasma and is a naturally occurring copper compound. GHK-Cu’s alleged functions may include potentially increasing collagen and glycosaminoglycan production in skin fibroblasts, encouraging blood vessel formation, attracting immune cells, serving as an antioxidant, and reducing inflammation. It has been speculated that this signal is created following tissue damage as feedback.

GHK-Cu Peptide and Stem Cells

Investigations purport that mechanistically, Glycine-Histidine-Lysine (GHK) may stimulate the release of trophic factors by mesenchymal stem/stromal cells.

This research suggested that GHK MSC-conditioned media appeared to have a higher vascular endothelial growth factor (VEGF) concentration, stimulating endothelial cell proliferation, migration, and tubule formation.

AOD-9604 Peptide

Research suggests that bone health may be improved by the peptide AOD 9604, which is essentially a fragment of GH without the proliferative impact. An IGF-1 and direct cellular pathway activator, it is an 8% fragment of the GH molecule. The IGF-1 pathway, a major contributor to insulin resistance, is believed to be unaffected by AOD 9604. 

This work suggested that AOD 9604 may stimulate osteogenesis in an MSC-osteogenic medium, as well as myoblast differentiation in vitro and chondrocyte synthesis of collagen and proteoglycan, raising the question of whether or not AOD 9604 may prevent bone loss and fragility in a rat model of osteoporosis. The data also suggests that AOD 9604 may contribute to helping bone and joint disorders in animal models.

ARA-290 Peptide

Linear peptide ARA 290 (IRR agonist) has 11 amino acids. Inflammation and tissue healing are hypothesized to be triggered by the IRR, a heteromer comprising the erythropoietin receptor and the beta-common (CD131) receptor. From what researchers can speculate experimentally, following peripheral nerve damage, the IRR may modify the neurogenic inflammatory response in the spinal cord.

This research speculated the impact of ARA290 in various illness models, including a neuropathy model. This peptide has been suggested to change the environment from one that may promote inflammation and tissue damage to one that may promote healing and repair in the animals used in this investigation.

Researchers interested in further studying these compounds can visit Core Peptides for the highest quality source of research compounds available online.

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